| ORIGINAL ARTICLE |
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| Year : 2023 | Volume
: 23
| Issue : 2 | Page : 111-118 |
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Acute pancreatitis due to hypertriglyceridemia: Plasmapheresis versus medical treatment
Gonca Koksaldi Sahin1, Muge Gulen1, Selen Acehan1, Nurdan Unlu2, Yilmaz Celik3, Deniz Aka Satar4, Mustafa Sencer Segmen1, Salim Satar1
1 Emergency Medicine Clinic, Adana City Training and Research Hospital, Health Sciences University, Adana, Turkey
2 Anesthesiology and Reanimation Clinic, Intensive Care Unit, Adana City Training and Research Hospital, Adana, Turkey
3 Gastroenterology Clinic, Adana City Training and Research Hospital, Health Sciences University, Adana, Turkey
4 Department of Histology and Embryology, Assisted Reproduction Unit, Andrology Laboratory, Adana City Training and Research Hospital, Health Sciences University, Adana, Turkey
Correspondence Address:
Muge Gulen
Emergency Medicine Clinic, Adana City Training and Research Hospital, Health Sciences University, Yuregir, Adana 01370
Turkey
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/tjem.tjem_276_22
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OBJECTIVE: Hypertriglyceridemia (HTG) is the third-most common cause of acute pancreatitis. Plasmapheresis is an extracorporeal treatment method used for treatment. This study aimed to investigate the efficacy of medical treatment and plasmapheresis in patients with acute pancreatitis due to HTG.
METHODS: This was a retrospective cross-sectional study. The patients were divided into two groups according to the treatment they received as those who received only medical treatment and those who performed plasmapheresis with medical treatment. According to the treatment received by the patients; clinical, demographic, and laboratory data, Ranson scores, and bedside index of severity in acute pancreatitis (BISAP) scores, decrease in triglyceride levels in 24 h, length of hospital stay, and outcomes were recorded.
RESULTS: Forty-seven patients were included in the study. The level of triglyceride decreases at the 24th h was 59.7% ±17.3% in those who received medical treatment and was 70.4% ±15.1% in those who received plasmapheresis (P = 0.032). Receiver operating characteristic curve analysis was performed to predict the need for plasmapheresis treatment, area under the curve (AUC) value of the triglyceride level was the highest (AUC: 0.822, 95% confidence interval: [0.703–0.940]; P < 0.001), the sensitivity and specificity were 83.3% and 72.4%, respectively, and the cut-off value of triglyceride was accepted as 3079.5 mg/dL.
CONCLUSION: Plasma triglyceride levels and BISAP score on admission may help physicians to predict the need for plasmapheresis. Plasmapheresis helps to rapidly reduce triglyceride levels in patients with HTG-associated acute pancreatitis.
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