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Table of Contents
Year : 2022  |  Volume : 22  |  Issue : 4  |  Page : 221-225

Tachycardia origin prediction using point of care ultrasound (TOP-UP) - A novel technique

1 Department of Emergency Medicine, Aarupadai Veedu Medical College and Hospital, Puducherry, India
2 Department of Emergency Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Date of Submission13-May-2022
Date of Decision29-Jul-2022
Date of Acceptance30-Jul-2022
Date of Web Publication01-Oct-2022

Correspondence Address:
Sasikumar Mahalingam
No 9, Vaigai Street, Vallalar Nagar, Nainarmandabam, Puducherry - 605 004
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2452-2473.357346

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Narrow complex tachycardia (NCT) is often due to supraventricular tachycardia (SVT). SVT with aberrancy, preexcitation, paced rhythm, rate-dependent bundle branch block, preexisting conduction defects or SVT due to drugs, and electrolyte abnormality can also be wide complex. Wide-complex tachycardia (WCT) is often ventricular tachycardia (VT), but fascicular VT (fVT) can present as NCT. Thus, WCT can be either VT or SVT. This has been a perplexing problem for the emergency physician for ages. Here, in this case series, we describe the novel use of point-of-care ultrasound to differentiate SVT from VT.

Keywords: Differential diagnosis, distinction, point of care testing, supraventricular tachycardia, TOP-UP technique, ultrasonography, ventricular tachycardia

How to cite this article:
Mahalingam S, Rajendran G, Nathan B, Ayyan M, Pillai VM. Tachycardia origin prediction using point of care ultrasound (TOP-UP) - A novel technique. Turk J Emerg Med 2022;22:221-5

How to cite this URL:
Mahalingam S, Rajendran G, Nathan B, Ayyan M, Pillai VM. Tachycardia origin prediction using point of care ultrasound (TOP-UP) - A novel technique. Turk J Emerg Med [serial online] 2022 [cited 2023 Sep 28];22:221-5. Available from: https://www.turkjemergmed.org/text.asp?2022/22/4/221/357346

  Introduction Top

Tachyarrhythmia (stable or unstable) is a common and potential life-threatening problem in the emergency department (ED). The basic step in tachyarrhythmia assessment is to differentiate supraventricular tachycardia (SVT) and ventricular tachycardia (VT) after ruling out sinus tachycardia. Conventionally, many algorithms have been used to differentiate wide-complex SVT (WC-SVT) and VT, but they have limited sensitivity and specificity. The patient's clinical features and electrocardiogram (ECG) can guide tachyarrhythmia differentiation; however, to date, electrophysiological (EP) study remains the gold standard. Hence, we propose a novel approach to differentiate SVT from VT using point-of-care ultrasound (TOP-UP).

  Case Report Top

Case 1

A 50-year-old male known to have triple-vessel disease (TVD) and recurrent VT presented to the ED with chest pain (retrosternal and diffuse) and breathlessness (NYHA 2–3) for 1 day and palpitation for 1 h. On arrival in the ED, the vitals were pulse rate (PR) of 150/min, blood pressure (BP) of 120/70 mmHg, respiratory rate (RR) of 20/min, and oxygen saturation (Spo2) of 97% in room air. The clinical examination was normal. The 12-lead ECG shows regular wide-complex tachycardia (WCT) and a heart rate of 157 beats per min [Figure 1]a. Since the patient had WCT and past history of TVD/recurrent VT, at first glance, it was thought to be VT. However, we could make out a clear inverted discernible P wave in lead II with a clear 1:1 AV association.
Figure 1: (a) Wide-complex tachycardia with heart rate of 157/min with discernible P waves in lead II and 1:1 association suggesting supraventricular tachycardia. (b) POCUS with subcostal view shows 1:1 association of Acw and Vcw suggesting supraventricular tachycardia

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Moreover, POCUS also showed a clear 1:1 association between atrial contraction waveforms (Acws) and ventricular contraction waveforms (Vcws) [Figure 1]b. There was a clear-cut concurrence with ECG AV association and POCUS findings. Although there was confusion initially, POCUS helped us in clinching the diagnosis (SV-WCT) with ease. The patient was initially tried with medical management (adenosine and amiodarone) and finally resorted to synchronized cardioversion.

Case 2

A 45-year-old hypertensive female patient came to the ED with a history of sudden-onset palpitation, breathlessness, and giddiness for 3 days. On arrival in the ED, the vitals were PR of 220/min, BP of 110/70 mmHg, RR of 20/min, and SpO2 of 98% in room air. Clinical examination was unremarkable. The 12-lead ECG showed regular WCT with a heart rate of 220 beats/min and no discernible P wave [Figure 2]a. As per the Brugada algorithm, the rhythm was classified as VT (R-to-S nadir >100 ms in one of the precordial leads, here V5, V6) [Figure 2]a. M-mode echocardiography (subcostal view) showed Vcw > Acw, strongly suggesting VT [Figure 2]b. The patient showed intermittent capture beats, while on amiodarone infusion, further confirming the rhythm to be VT.
Figure 2: (a) Wide-complex tachycardia with a heart rate of 220/min with no discernible P waves suggesting Ventricular tachycardia. (b) POCUS with subcostal view shows Vcw more than Acw suggesting ventricular tachycardia

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We obtained written informed consent from all the patients.

  Discussion Top

Dealing with tachyarrhythmias in a highly crowded, busy ED is often challenging. It needs in-depth knowledge regarding ECG to decipher and treat any tachyarrhythmias appropriately. It is of great importance to differentiate VT from SVT since inappropriate acute management can lead to poor outcomes.

Wide-complex supraventricular tachycardia, narrow complex VT – A right mismatch sometimes

Both SVT and VT can present as either narrow complex tachycardia (NCT)/WCT. The above mismatch complexity led to various ECG algorithms, namely the Brugada algorithm, Vereckei's aVR algorithm, Pava algorithm, Wellens criteria, Kindwall criteria, and Griffith algorithm, for differentiating WC-SVT and VT. Fascicular VT (fVT) involving the His-Purkinje reentry path can present as NCT. There are no ECG algorithms to differentiate fVT from SVT.

Although various algorithms are available, most of them are complicated, multistep, and difficult to remember. While a few algorithms are easy, the diagnostic accuracy is low. The confusion can still increase when the algorithm-based ECG diagnosis is wrong based on the gold standard EP diagnosis. These mismatches can lead to unnecessary delays in diagnosis and treatment in an ED. This delay is more among stable tachyarrhythmia, where the treatment is mainly dependent on the subtype of tachyarrhythmia. Unstable tachyarrhythmia needs to be cardioverted immediately; hence, origin prediction is not necessary for an acute situation.

Clinical prediction and existing electrocardiogram algorithms for differentiating wide-complex tachycardia

Clinical history and physical examination can aid in differentiating WCT. History of prior myocardial infarction, congestive cardiac failure favors VT. Clinical findings suggesting AV dissociation namely cannon A waves in the jugular venous pulse, varying intensity or widely split S1 on cardiac auscultation, variable arterial pressure unrelated to breathing favors VT. A young-aged person with no previous comorbid conditions, with sudden-onset tachycardia, tachycardia termination by carotid sinus massage, Valsalva maneuver, adenosine, or verapamil favors SVT. However, fVT can also respond to Valsalva maneuver, adenosine, and verapamil. Although VT often presents with hemodynamic compromise, stable WCT is not necessarily SVT.[1],[2]

AV dissociation, fusion beat, capture beat, northwest axis, precordial concordance, positive aVR, RBBB QRS >140 ms, and LBBB QRS >160 ms are some of the traditional VT diagnostic criteria.[3],[4] WCT in a patient with preexisting AV conduction block will be VT unless proved otherwise.[2] In SVT with aberrancy, LBBB with right axis deviation is uncommon. In VT, RBBB with the normal axis is rare. In SVT, the initial QRS electrical vector moves rapidly in the beginning and slowly at the end. In contrast, slow conduction happens throughout the QRS in VT.[5] If the QRS complexes of WCT are like those of baseline ECG, the chances are good that the WCT is SVT.[5]

Various ECG algorithms had been proposed for differentiating WC-SVT and VT. Among them, the Brugada algorithm is the most widely used one. Despite the numerous criteria, accurate diagnosis of WCT remains a challenge.[6] Many studies were unable to corroborate Brugada's and Vereckei's original articles' high sensitivity and specificity.[3],[4] The Basel algorithm, limb lead algorithm, and inferior lead Q-wave algorithm are the three newer ECG algorithms that have recently been proposed to differentiate VT from SVT in WCT.[7],[8],[9] The limitations of current existing algorithms are the complexity of algorithms, less diagnostic accuracy, and the chance of misdiagnosis of preexcited SVT/fascicular VT/wide complex atrial flutter.

Need for a newer algorithm – the TOP-UP technique

When there is still an ambiguity after clinical and ECG prediction, the only option left out currently is the gold standard invasive EP study. There is a compelling need for a newer and simpler technique to bridge this gap in clinical practice. We had a very simple idea of using POCUS to decipher WCT as SVT or VT. SVT would have an equal or a greater number of P waves than QRS, resulting in an AV ratio of ≥1. Since VT does not necessitate atrial activity, the AV ratio is often <1.[5] Very rarely, VT can have 1:1 AV conduction. Using POCUS, we extrapolated the above concept using M-mode/AMM along the atrium and ventricle to look for contraction waveforms. We tried this and found it to have a good correlation with the final diagnosis.

Only 20% of the VT ECGs show AV dissociation, and sometimes, P waves will be buried within the QRS complexes. Hence, the novel TOP-UP technique can unravel those findings and act as a bridge to assess atrioventricular association/dissociation for differentiating SVT and VT. However, more diagnostic accuracy studies are still required. It can make a drastic change in the tachyarrhythmia approach in ED if this interesting concept is shown to have good diagnostic accuracy in future studies. With more echocardiographic experience, echocardiography may become a standard investigation for diagnosing WCT in the future.[10]

How to perform and interpret the TOP-UP technique

Steps to perform the TOP-UP technique are as follows:

Step 1: Patients with stable tachyarrhythmia who have either NCT or WCT should be chosen.

Step 2: M/AMM mode with a faster sweep rate in the parasternal long-axis view, apical four-chamber view (A4C), or subcostal view (SC) will show Acw and Vcw.

Step 3: Tachycardia origin can be determined based on the number of Acw and Vcw (atrioventricular association/dissociation), as shown in [Figure 3].
Figure 3: TOP-UP technique protocol and interpretation technique

Click here to view

Right-sided chambers are the least affected by coronary artery disease. Echocardiographic A4C and SC views provide a better view of right-sided cardiac chambers.[10] Hence, right-sided chambers may be the preferred chambers for the TOP-UP technique. A special mention of anatomical M-mode (AMM), where one can move M-mode along any cardiac chambers, needs to be studied. The use of AMM will greatly simplify this technique. The protocol followed is given in [Figure 3].

Strength and limitations of the TOP-UP technique

The technique is a) very simple and repeatable by an ECHO-trained person, b) can differentiate between VT and SVT, c) can reduce time delay in treating stable tachyarrhythmia, and d) a perfect point-of-care tool for an emergency physician in the acute treatment of tachyarrhythmia.

Few limitations include (a) it cannot differentiate subtypes of SVT, (b) one can mistake VT with 1:1 VA conduction (extremely rare) for SVT because ECHO cannot distinguish between anterograde and retrograde conduction, (c) M-mode along the left ventricular regional wall motion abnormality can yield inaccurate findings, and (d) a poor ECHO window in obese patients can impede diagnostic ability.

  Conclusion Top

The novel “TOP-UP” technique can differentiate WCT and NCT as either SVT or VT. Although TOP-UP had a clear concurrence with actual diagnosis in the above cases, further clinical research with more patients is needed to determine its sensitivity, specificity, and diagnostic accuracy. Hence, it should not be used as a sole method for differentiating tachyarrhythmia; rather, it should be coupled with clinical and ECG criteria. If proven to have good diagnostic accuracy, the TOP-UP technique will simplify emergency management of stable tachyarrhythmia and shorten recovery time.

Author contributions

SM: Conceptualization (lead), Resources (lead), Writing-original draft (lead), Writing, Reviewing and Editing (lead). GR: Conceptualization (equal), Writing Reviewing and Editing (equal). BN: Conceptualization (equal), Writing Reviewing and Editing (equal). MA: Conceptualization (supporting), Writing Reviewing and Editing (supporting). VMP: Conceptualization (supporting), Writing Reviewing and Editing (supporting).

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patients have given their consent for their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Conflicts of interest

None declared.



  References Top

Garner JB, Miller JM. Wide complex tachycardia – Ventricular tachycardia or not ventricular tachycardia, that remains the question. Arrhythm Electrophysiol Rev 2013;2:23-9.  Back to cited text no. 1
Sousa PA, Pereira S, Candeias R, de Jesus I. The value of electrocardiography for differential diagnosis in wide QRS complex tachycardia. Rev Port Cardiol 2014;33:165-73.  Back to cited text no. 2
Sundhu M, Yildiz M, Gul S, Syed M, Azher I, Mosteller R. Narrow complex ventricular tachycardia. Cureus 2017;9:e1423.  Back to cited text no. 3
Alzand BS, Crijns HJ. Diagnostic criteria of broad QRS complex tachycardia: Decades of evolution. Europace 2011;13:465-72.  Back to cited text no. 4
Miller JM, Yadav AV. Wide complex tachycardias – The differential diagnosis remains wide and complex. US Cardiol 2007;4:48-9.  Back to cited text no. 5
Preza PM. Echocardiographic diagnosis of ventricular tachycardia: Is there a problem with clinical and electrocardiographic diagnostic criteria? Response. Rev Esp Cardiol (Engl Ed) 2016;69:354.  Back to cited text no. 6
Chen Q, Xu J, Gianni C, Trivedi C, Della Rocca DG, Bassiouny M, et al. Simple electrocardiographic criteria for rapid identification of wide QRS complex tachycardia: The new limb lead algorithm. Heart Rhythm 2020;17:431-8.  Back to cited text no. 7
Subramany S, Kattoor AJ, Kovelamudi S, Devabhaktuni S, Mehta JL, Vallurupalli S, et al. Utility of inferior lead Q-waveforms in diagnosing ventricular tachycardia. Clin Med Insights Cardiol 2020;14:1-5.  Back to cited text no. 8
Moccetti F, Yadava M, Latifi Y, Strebel I, Pavlovic N, Knecht S, et al. Simplified integrated clinical and electrocardiographic algorithm for differentiation of wide QRS complex tachycardia: The basel algorithm. JACC Clin Electrophysiol 2022;8:831-9.  Back to cited text no. 9
Wren C, Campbell RW, Hunter S. Role of echocardiography in differential diagnosis of broad complex tachycardia. Br Heart J 1985;54:166-72.  Back to cited text no. 10


  [Figure 1], [Figure 2], [Figure 3]


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